Police seized millions of methamphetamine pills from alleged drug smugglers along Thailand's border with Myanmar.

Authorities tightened security at road checkpoints following a directive from the Central Investigation Bureau to crack down on suspected drug syndicates trafficking contraband through the northern province of Tak.

Tak traffic cops said they received a report of a 'suspicious' pickup truck believed to be transporting drugs along Phahonyothin Road into central Thailand on November 9.

Police signaled for the vehicle to stop, but it reportedly sped away. The driver and a passenger were then said to have pulled over and fled into a dense roadside forest on foot.

Officers searched the pickup and found 30 bags inside containing six million meth pills labelled 'WY'. The pills were wrapped in yellow stencil paper marked with five red stars and the number 999.

The hard drugs handed over to the Bantak Police Station.

Police Lieutenant Colonel Pitchaya Tawichsri of the Department of Highways said: 'We will continue the investigation to identify the network involved and ensure the escaped suspects are brought to justice.'

Thailand has become a notorious hub for drug production and trafficking. In the north of the country, the ‘Golden Triangle' area shares borders with Laos and Myanmar, and has produced large amounts of opium since the 1950s but focus in recent years has shifted to the more profitable methamphetamine.

Bloomberg citing data from the United Nations Office on Drugs and Crime reported that a record 169 tonnes of methamphetamine was seized in SEA last year, 82 per cent of which came from the Golden Triangle.

At its heart lies the Golden Triangle Special Economic Zone (GTSEZ), run by Chinese business tycoon and suspected crime boss Zhao Wei in the Chinese vassal state Laos.

In 2007, Zhao brokered a deal with the Laos government and obtained a 99-year lease to build the zone on a 39-square mile patch of impoverished Bokeo province.

The Chinese businessman claims to be a benefactor as he touts the GTSEZ as a tourist and economic hub designed to bring more income and investments into the country. However, both local and international law enforcement agencies believe it is a front for organised crime, including human trafficking, drug trafficking, and call-centre scams.

International authorities have struggled to take down the gambling empire as the Laos government itself is said to be protecting the GTSEZ, in which it has a 20 per cent stake.