Footage shows terrified locals fleeing as an entire building collapsed following the devastating earthquake in Turkey.

The video shows people running away from the multi-storey structure levelled by the tremors that hit Gaziantep province on February 6.

A catastrophic magnitude 7.8 quake, measured at a depth of 24.1 kilometres, hit 23 kilometres east of Nurdagi in Gaziantep province at around 4 am on Monday, the United States Geological Survey said.

Several aftershocks, including quakes of magnitudes 6.7 and 7.5, struck the same region hours after.

As of Thursday morning, the total death toll in Turkey and Syria has reached 15,383, with World Health Organization officials warning that it could climb up to 20,000.

Rescuers are still racing to find trapped survivors even as 'extremely severe' weather conditions hamper their efforts.

The tragic earthquake is said to be among the strongest to hit Turkey in the last century.

Turkey's Vice President Fuat Oktay said authorities were also struggling with 'extremely severe weather conditions'.

TV correspondent Sinem Koseoglu said that 'everywhere there is snow or rain, and it's very cold'.