A small girl was filmed applying medicine to a huge 4.5-metre Burmese python to treat its mouth ulcer in central Indonesia.

Maharani, the three-year-old girl also famous for a video of her brushing her pet crocodile's teeth, can be seen swabbing the python's gums to treat 'sprue', or a mouth ulcer, in this clip filmed in Tangerang City on April 9.

Reportedly Maharani got her animal-loving nature from her father, who provides care for injured exotic animals, and has been interacting with the dangerous reptiles since she was two-years-old.

Effendi, when asked about concerns for his daughter's safety with these animals, commented: "I understand what the others' feeling. It is true that I am sometimes scared, but after seeing her interaction with the animal, the scary feeling goes away.

"First time she plays with a wild animal, I always watch and give directions what to do. But now, she has understood what to do as well as what is restricted when with an animal.

"Every time she cures the animal, Maharani always cries and the animal will follow what she need them to do.

"It is never easy to handle a python with sprue. The animal must be stressed and doesn't want to be touched.

"When my mother touched the python, it twisted on her arm very tight and hurt her. But when Maharani took care of it, the python relaxed and strengthened its body.

"To be honest, currently I don't have any worries about her when playing with animals. I don't know why. I believe in her, and so do the animals."

A girl takes care of a 4,5-meter python that is diagnosed with sprue on its mouth in Tangerang, Indonesia. The girl uses a cotton bud to put the external medicine on the mouth of the giant snake.