CCCTV captures the dramatic moment a UPS cargo plane erupts in a fireball as it crashes during take-off.

The aircraft was seen catching fire while leaving the Louisville Muhammad Ali International Airport in Kentucky on Tuesday evening.

Seconds later, the wide-body aircraft crashed and burst into flames, killing at least three people and injuring 11 others.

Reports said the McDonnell Douglas MD-11, carrying three crew members, was bound for Honolulu.

Governor Andy Beshear said: 'We have some initial numbers, but let me tell you I expect them to grow. Right now, we believe we have at least three fatalities.

'I believe that number is going to get larger. We have at least 11 injuries, some of them very significant, that are being treated by local hospitals.'

The cargo airline operates its global hub at the airport.

The Federal Aviation Administration (FAA) said in a statement: 'UPS Flight 2976 crashed around 5:15 pm local time on Tuesday, Nov. 4, after departing from Louisville Muhammad Ali International Airport in Kentucky.'

Flight tracking data suggests the aircraft appeared to struggle to gain altitude and went down near the end of the runway, indicating a possible mechanical issue rather than an air traffic control problem.

Investigators are working to determine the cause of the crash.

The airport said all inbound and outbound flights have been suspended, and the airfield remains temporarily closed.