Scientists at Case Western Reserve University are breaking new ground in prosthetics, developing technology that allows artificial hands to feel touch, making them feel like a natural part of the body.

The U.S. Department of Defense Congressionally Directed Medical Research Program has awarded the team a $9.9 million grant to fund a clinical trial of sensory-enabled neuro-controlled prostheses. The trial will recruit 12 participants with upper-limb amputations to compare traditional prosthetic arms with the advanced devices developed at Case Western Reserve since 2015.

“People with upper-limb-loss deserve to have better technologies that can improve their lives,” said Emily Graczyk, assistant professor of biomedical engineering at the Case School of Engineering and School of Medicine, and investigator at the Cleveland VA, who is leading the research.

The neuroprosthesis, named iSens, uses implanted electrodes to sense muscle movement and stimulate nerves, sending touch feedback from the prosthetic fingertips to the brain. A neural control device implanted in the arm communicates with the prosthesis via Bluetooth.

The four-year study will unfold in three phases: participants will first be evaluated using their current prostheses, then receive implantation and calibration of the iSens system, and finally use the device in randomized trials comparing touch sensation and advanced motor control. Surveys and laboratory assessments over approximately 18 months will track functionality and quality of life improvements.

“The significant funding allows us to complete this clinical trial that wouldn’t necessarily get venture capital investment at this stage,” said Dustin Tyler, Arthur S. Holden Professor of biomedical engineering and co-investigator.

Researchers hope the trial will demonstrate how enhanced sensation and control can improve independence, self-image, and social engagement for people living with upper-limb loss.